Category Archives: Uncategorized

Pfallergan Round II?

<<Trump Executive Order Could Revive Allergan-Pfizer Merger -Emily Stewart   TheStreet.com    April 22,  2017 The Trump administration’s executive order on tax regulations could revive the defunct Allergan-Pfizer merger. The White House on Friday unveiled a new executive order instructing the Treasury … Continue reading

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Parsley, SAGE, Marathon, and Timing

–with apologies to Simon and Garfunkel, 1966 SIDE A NIR has long been an admirer of how SAGE Therapeutics has been able to leverage predictive power from tiny pilot studies in Severe Status Epilepticus (SRSE) and Post-Partum Depression (PPD)—but today’s … Continue reading

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The Lunatics Have Taken Over The Asylum

“The lunatics have taken over the asylum The lunatics have taken over the asylum The lunatics have taken over the asylum – take away my right to choose The lunatics have taken over the asylum – take away my point … Continue reading

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ToneDeaf Therapeutics

(from NeuroPerspective Jan-Feb 2017) (Cambridge, MA 12/8/16):  ToneDeaf Therapeutics, a startup company based in Cambridge, today announced they have obtained seed funding from undisclosed investors with which they will take their cutting-edge Auditory-Reception-Facilitation device, ARF, into IND-preparation. “It is tragic … Continue reading

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Mr. Robot and the Amyloid Hypothesis

“Maybe we’re all just stumbling from the right questions to the wrong answers, or maybe from the right answers to the wrong questions.”                                   … Continue reading

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Sola’s EXPEDITION3 Fails

Back in 2013, NIR used a picture of an ill-fated South Pole expedition in a presentation at CNS Summit. The caption read: “Lilly announced it will run another major Phase III program for solanezumab. Patients must show scan or CSF … Continue reading

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SAGE and PPD

SAGE Therapeutics’ remarkable run with tiny-n pilot studies as predictors of Phase II results continued when SAGE-547 separated remarkably well in a larger (albeit still very small, 21pt study) trial in severe Post-Partum Depression. A single injection provided remission of … Continue reading

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