Category Archives: Science

Academic Opioid Leapfrogs Field–Perhaps

Nature was the venue (8/18/16) for the publication of a paper from academic collaborators at UCSF, Stanford, UNC, Friedrich-Alexander-Universität Erlangen-Nürnberg, and Parelcus Medical University, a paper that reported the development of a highly refined, selective mu opioid agonist that–in animal … Continue reading

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Forum and CIAS

Forum Pharmaceuticals (formerly EnVivo) announced today that their two Phase III trials of FRM-6124 in CIAS (Cognitive Impairment Associated with Schizophrenia) failed to hit their co-primary endpoints.   No details were provided, but there apparently are signs of a treatment effect … Continue reading

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Anything But Static: The Coming Era of Massive Paradigm Shifts

One of NIR’s favorite concepts–and one that almost invariably finds its way into our conference presentations and Innovation Reviews–is that of Treatment Paradigm Shifts. A TPS is a tangible and meaningful addition to the repertoire of what is available for … Continue reading

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FRM-6124 Trials Halted

There is a highly credible report that the Forum Pharmaceuticals Phase III trials for encenicline/FRM-6124 are being halted due to a safety issue: Gastric hypomotility setting the stage for eventual gut perforation. FRM-6124 is a program that NIR has long … Continue reading

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mAbMEN: It’s Not Over

Eli Lilly: Experimental Alzheimer’s drug shows some benefit  (AP) Eli Lilly’s Solanezumab Is the Alzheimer’s Drug Equivalent of the Internet Dress                (TheStreet) Lilly says drug slows Alzheimer’s in patients with mild disease (Reuters) Lilly’s Alzheimer’s Drug May Slow Patients’ Decline … Continue reading

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Sages and Mariners

The report from SAGE Therapeutics about their pilot data in Post-Partum Depression (PPD) raised plenty of eyebrows, (and their market cap, briefly, by about $420 million). A planned fifteen patient study was cut short after the first four patients showed … Continue reading

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Aducanumab: Less Than Meets The Eye

The beta-amyloid target in Alzheimer’s has become, to put it politely, somewhat tarnished over the past several years. AN-1792, bapineuzumab, solanezumab, gantenerumab, plus several BACE and gamma-secretase inhibitors/modulators, have combined to form a conga-line of clinical disappointments, undulating its way … Continue reading

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